Tools for fragment based drug discovery

ZOBIO NMR PYRAMID

< Structural BiologyX-ray Crystallography >

ZOBIO NMR PYRAMID®


The ZoBio NMR Pyramid® illustrates the different levels of structural information on ligand – target complexes that can be obtained by NMR. At the bottom of the NMR Pyramid, Competition Binding experiments provide low resolution structural information on the binding location of ligands with minimal requirements to the protein. Moving upwards through the Pyramid, isotope labeled protein is required and increased NMR efforts are needed, which leads to higher resolution structural information.

Competition Binding / Binding Site Location / Binding Orientation / Structure Elucidation

NMR_Pyramid

Click on the NMR Pyramid for a description of the different stages of the NMR Pyramid, starting with
Competition Binding experiments and moving up to full NOE-based Structure Elucidation by NMR.

< Structural BiologyX-ray Crystallography >