Tools for fragment based drug discovery



25 January 2018, Leiden, NL

ZoBio is looking for an experienced and motivated assay development specialist with a proven industrial track record designing and setting-up biochemical assays. Initially for a period of 12 months, it is fully expected that the successful candidate will become a permanent and integral member of the ZoBio team.

Application deadline: 31 March 2018

Start date: As soon as possible

Primary duties

  • As a member of biochemical and biophysical assay team, he/she will work on method development, qualification and characterization of small molecule interaction with biological targets for clients’ drug discovery projects.
  • Responsibilities include designing, execution of experiments, documenting results accurately in laboratory notebooks (ELN), participating in meetings with our clients and preparing and reviewing reports.
  • Applies technical knowledge with minimal supervision to independently execute method development and assay remediation activities.


  • 60% Design and execution of experiments
  • 20% Supervision of junior scientists
  • 20% Writing/reviewing reports for clients

Education and Experience Requirements

  • PhD with 1-2 years of industry experience or MSc. with 4-6 years of industry experience in biochemistry/enzyme assays or other biological/analytical discipline
  • Experience in method development, qualification and validation of analytical methods for small molecule – protein interaction studies
  • Experience with biophysical methods for protein-ligand interaction, such as Surface Plasmon Resonance technology (e.g. Biacore) is a plus
  • Experience in Statistical Analysis is a plus

Key skills, Abilities and Competencies

  • Strong analytical and problem-solving skills are required
  • In-depth knowledge of enzyme activity measurements, including both theory and practice is required
  • Ability to work in both a team as well as independently
  • Ability to work in a rapidly changing environment and able to handle working on multiple projects simultaneously
  • Good written and verbal communication skills are essential
  • Experience working with plate based assays preferred, especially with one or more of the following methods: fluorescent based assays e.g. TR-FRET, FP and other commercially available fluorescence assays

Please send your application (CV, motivation letter and names of potential referees) to the attention of Dr. Rob Heetebrij at clearly mentioning ‘Senior Scientist – (M/F) in Assay Development and Screening’ in your subject line.

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