Tools for fragment based drug discovery



18 April 2017, Leiden, NL

About ZoBio
ZoBio is a privately held, self-funded, successful and growing company that was spun out of Leiden University in 2004. ZoBio is a contract research organization (CRO) that offers a wide array of research services in the field of small molecule drug discovery. We are a leading innovator in developing a variety of biophysical techniques and tools that support hit-to-lead programs in the pharmaceutical industry.

Currently (April 2017) we are looking for a talented individual that can strengthen our assay group, in particular the Surface Plasmon Resonance (SPR) team. The successful candidate will have demonstrated expertise in biophysical assay development using SPR technology (or related technologies) and the aptitude to learn other techniques. The appointment will initially be for a period of 12 months, extendable upon mutual agreement.

Start date: ASAP.

Job profile
The assay group plays a key role in our organization by screening, characterizing and quantifying small molecule-protein interactions. The assay group develops and uses biochemical (e.g. enzyme inhibition) and biophysical (e.g. SPR on Biacore T200 and 4000, thermal shift assays) methods to characterize the interaction of small molecules with proteins that are the targets of commercial drug discovery projects.

Profile of the applicant

  • Master degree or higher in biophysics, biochemistry or a related discipline.
  • Experience in analytical method development, in particular SPR or related binding assays
  • Experience with quantitative analysis (kinetics and affinity) of small molecule-protein interactions using Biacore Surface Plasmon Resonance (SPR) or other related technologies (e.g. biolayer or wave guided interferometry)
  • Having some experience in operating Biacore instruments (T200, 4000) is preferred but not a prerequisite.
  • Experience in protein characterization techniques (FPLC/HPLC, SDS-PAGE, Western blot, optical spectroscopy, DLS) would be useful, but not necessary.
  • Able to work in a result-driven, goal oriented environment.
  • An analytical mindset and a systematic approach to problem solving.
  • Well-organized, flexible and willing to grow to be able to manage concurrent projects while meeting deadlines.
  • Open and pro-active attitude; ability to understand and document data and communicate effectively within a team, yet function independently.
  • Good communication and writing skills in English are a must.
  • Good command of Word, Excel and Power Point is essential.

Please send your application to: clearly mentioning ‘scientist position assay group April 2017’ in your subject line.

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