Tools for fragment based drug discovery

NEWS

SCIENTIST (M/F) POSITION IN BIOPHYSICAL AND BIOCHEMICAL ASSAYS AVAILABLE AT ZOBIO

SCIENTIST (M/F) POSITION IN BIOPHYSICAL AND BIOCHEMICAL ASSAYS AVAILABLE AT ZOBIO 18 April 2017, Leiden, NL About ZoBio ZoBio is a privately held, self-funded, successful and growing company that was spun out of Leiden University in 2004. ZoBio is a contract research organization (CRO) that offers a wide array of research services in the field of small molecule drug discovery. We are a leading innovator in developing a variety of biophysical techniques and tools that support hit-to-lead programs in the pharmaceutical industry. Currently (April 2017) we are looking for a talented individual that can strengthen our assay group, in particular … Continue reading

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ZOBIO EXTENDS NMR STRUCTURAL BIOLOGY COLLABORATION WITH SANOFI

ZOBIO EXTENDS NMR STRUCTURAL BIOLOGY COLLABORATION WITH SANOFI 29 January 2016, Leiden, NL ZoBio announced today it will continue the collaboration with Sanofi in which ZoBio is providing critical 3D structure information to guide hit-to-lead studies. In the collaboration, ZoBio is using its expertise in nuclear magnetic resonance (NMR) of proteins and its unique access to high field NMR instrumentation to provide high resolution structures in a timely manner. Despite having high resolution X-ray crystallographic structures of the protein, deriving structural information on target-inhibitor complexes has proven challenging. In some cases, it has not proven possible to “soak” the inhibitor … Continue reading

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ZOBIO MOVES INTO BIOPARTNER 2 BUILDING

ZOBIO MOVES INTO BIOPARTNER 2 BUILDING 8 January 2016, Leiden, NL We are happy to announce that as of January 4th ZoBio operates from the BioPartner 2 building of the Leiden Bio Science Park. Moving into the BioPartner building allows us to continue growing and better serve our customers needs. The new building is located directly opposite to our former location within the Leiden University. This ensures continuous access to the NMR spectrometers we need to service our client’s needs in a timely manner and under any circumstances. ZoBio B.V., BioPartner 2 building, J.H. Oortweg 19, 2333 CH Leiden, The … Continue reading

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ZOBIO SECURES ADDITIONAL ACCESS TO HIGH FIELD NMR SPECTROMETERS THROUGH COLLABORATION WITH THE UNIVERSITY OF UTRECHT

ZOBIO SECURES ADDITIONAL ACCESS TO HIGH FIELD NMR SPECTROMETERS THROUGH COLLABORATION WITH THE UNIVERSITY OF UTRECHT 14 July 2015, Leiden, NL ZoBio and the laboratory of Prof. Marc Baldus at the Bijvoet Center for Biomolecular Research have started a collaboration enabling ZoBio access to Utrecht’s 900 MHz high field NMR spectrometer. Over the last couple of years, the demand for NMR based structural biology and protein observed NMR has significantly increased within ZoBio. With this collaboration, ZoBio now has secured access to the 900 MHz instrument in Utrecht (1 hour’s distance) as well as 850 and 600 MHz NMR spectrometers … Continue reading

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ANNOUNCING HEAD START PROJECTS

ANNOUNCING HEAD START PROJECTS 14 July 2015, Leiden, NL For more than 10 years the only way to access ZoBio technology was to start at the beginning with screening a fragment library. We are now happy to announce the availability of 4 head start projects: the kinases PIM1 and EphA4, Bromodomains and MDM4. With these programs, structural biology has already been fully enabled within ZoBio by either X-ray crystallography, NMR or both. In addition, orthogonally validated fragment-hit matter is also available, along with 3D structures of some ligand-target complexes. These turnkey projects can be swiftly initiated with full confidence of … Continue reading

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COLLABORATION WITH PROF. ANDREAS PLUCKTHÜN INITIATED TO DEVELOP NMR-BASED METHODS FOR ELUCIDATION OF THE STRUCTURE OF GPCR-LIGAND COMPLEXES

COLLABORATION WITH PROF. ANDREAS PLUCKTHÜN INITIATED TO DEVELOP NMR-BASED METHODS FOR ELUCIDATION OF THE STRUCTURE OF GPCR-LIGAND COMPLEXES 14 July 2015, Leiden, NL Recently, ZoBio and the laboratory of Prof. Andreas Pluckthün at the University of Zürich have started a collaboration funded through the Eurostars program. The primary goal of the project is to apply paramagnetic methods presently used within ZoBio to elucidate the structure of GPCR-ligand complexes. Currently, X-ray crystallography is the only structural method that is applied to GPCRs. However, two limitations to crystallography are routinely observed. First, the resolution of structures is often insufficient to observe or … Continue reading

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ZOBIO AND DOMAINEX JOIN FORCES TO DELIVER CRUCIAL DRUG TARGET INFORMATION TO SUPPORT FORMA THERAPEUTICS’ DRUG DISCOVERY PROGRAMS

ZOBIO AND DOMAINEX JOIN FORCES TO DELIVER CRUCIAL DRUG TARGET INFORMATION TO SUPPORT FORMA THERAPEUTICS’ DRUG DISCOVERY PROGRAMS 8 December 2014, Leiden, NL Today ZoBio and Domainex Ltd. (Cambridge, UK) announce a collaboration with FORMA Therapeutics (Watertown, MA, USA) to provide NMR-based structural biology services for a substantial panel of FORMA drug targets. The goal of the collaboration is to use ZoBio’s expertise in protein nuclear magnetic resonance (NMR) to elucidate the molecular basis for compound-target interaction, to complement ongoing X-ray crystallography approaches. NMR is currently the only alternative to crystallography capable of elucidating atomic resolution, 3D structural information. Under … Continue reading

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ZOBIO IS PLEASED TO ANNOUNCE THE PURCHASE OF A BIACORE™ 4000 INSTRUMENT

ZOBIO IS PLEASED TO ANNOUNCE THE PURCHASE OF A BIACORE™ 4000 INSTRUMENT 5 September 2014, Leiden, NL ZoBio has offered SPR services for amongst other things, fragment hit confirmation, for 3 years using our Biacore™ T200. The orthogonality and quantitative nature has made SPR a powerful complement to our TINS fragment screening technology. As a result, SPR has become any integral part of nearly every project and we have therefore, decided to invest in increased capacity. Our new Biacore™ 4000 will have approximately 4 times the throughput of the T200 which it joins. Together, the 2 instruments will insure that … Continue reading

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HIGH THROUGHPUT PROTEIN PREPARATION FOR STRUCTURAL BIOLOGY

HIGH THROUGHPUT PROTEIN PREPARATION FOR STRUCTURAL BIOLOGY 5 September 2014, Leiden, NL Structural biology is a critical part of the modern process of drug design. X-ray crystallography is the primary means to determine 3D structures of target-ligand complexes, however, the industry is beginning to realize that crystallography has its limitations. What do you do when crystallography fails? NMR is the only alternative that can provide atomic resolution structural information and by developing rapid, cost effective approaches, NMR-based structural biology has grown explosively at ZoBio. Similarly to crystallography, often the rate-limiting step is the ability to produce large quantities of a … Continue reading

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COLLABORATION WITH DOMAINEX

COLLABORATION WITH DOMAINEX 5 September 2014, Leiden, NL In order to further strengthen our capabilities in NMR-based structural biology, ZoBio has initiated a collaboration with Domainex located in Cambridge, UK. Following on from the previous article, sometimes using bioinformatics to generate 5-15 constructs does not lead to a well-expressed, well-behaved protein. Domainex has developed a proprietary technology called Combinatorial Domain Hunting (CDH) that generates 10,000’s of open reading frames in which both the N and C termini are varied. The clones are systematically screened for those that produce high levels of soluble, functional protein with the entire process typically requiring … Continue reading

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